The New “Endemic Phase” and a Vaccine Update

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In this Covid Grand Rounds, we’ll begin with a pandemic update from Monica Gandhi and Peter Chin-Hong. We’ll discuss the CDC’s new mask guidance, the Omicron sub-variant, infection-related and hybrid immunity, and what it means to enter the “endemic phase.”

In the second segment, Bonnie Maldonado of Stanford University will give us a vaccine update, including the evidence of waning immunity after vaccination, the prospects for a second booster, the state of vaccines for children, and new vaccine candidates, including Omicron-specific boosters. The session will be moderated by Bob Wachter.

Peter Chin-Hong, MD, Professor of Medicine, Division of Infectious Diseases at UCSF Health; Associate Dean for Regional Campuses, UCSF School of Medicine

Monica Gandhi, MD, MPH, Professor of Medicine; Associate Chief of Division of HIV, Infectious Diseases, and Global Medicine at ZSFG; Director of the UCSF-Gladstone Center for AIDS Research; Medical Director of the HIV Clinic, Ward 86, ZSFG

Yvonne Maldonado, MD, Professor and Chief of the Division of Infectious Diseases, Dept. of Pediatrics at Stanford University School of Medicine; Senior Associate Dean for Faculty Development and Diversity at the Stanford School of Medicine

Note: Closed captions will be available within 48-72 hours after posting.

Bob Wachter: Introduction
00:02:46-00:29:43 – Pandemic update with Monica Gandhi (Professor of Medicine; Associate Chief of Division of HIV, Infectious Diseases, and Global Medicine at ZSFG; Director of the UCSF-Gladstone Center for AIDS Research; Medical Director of the HIV Clinic, Ward 86, ZSFG)
and Peter Chin-Hong (Professor of Medicine, Division of Infectious Diseases at UCSF Health; Associate Dean for Regional Campuses, UCSF School of Medicine)
00:29:45-01:03:05 – Vaccine update with Yvonne Maldonado (Professor and Chief of the Division of Infectious Diseases, Dept. of Pediatrics at Stanford University School of Medicine; Senior Associate Dean for Faculty Development and Diversity at the Stanford School of Medicine)
Bob Wachter: Closing

See previous Medical Grand Rounds:
• February 24: Clinical Problem Solving with Lisa Winston

YouTube video

• February 10: The 24th Annual Reza Gandjei Memorial Lecture: A Fireside Chat with Megan Ranney
YouTube video

• February 3: The Downslope of the Omicron Surge, and What to Do as We Turn the Corner
YouTube video

• January 27: Rebuilding What We’ve Lost in Covid: A Perspective from the ICU
YouTube video

See all UCSF Covid-19 grand rounds, which have been viewed over 3M times, here:


Disclaimer: This content including advice provides generic information only. It is in no way a substitute for a qualified medical opinion. Always consult a specialist or your own doctor for more information.

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  1. Did we know at what tissue temperature did SARS COV2 better replicate?
    At TWiV659 at min.29 Christian Drosten indicate very low tissue temperature better to replicate SARS COV2.
    May be ,,mask wearing,, increase also mucoseal respiratory temperature, and diminish SARS COV2 replication?

  2. bizarre that this anti-masker wierdo monica ghandi is being invited to these talks. mehdi hassan and dr funk already exposed her as a fraud

  3. This discussion here of the data on myocarditis and pericarditis emphasizes "longer intervals" between boosters to reduce risks, particularly for males aged 18-24, and emphasizes that the risks per million are "low." WHY is there no mention whatsoever of the data on the risks introduced by vaccine administration that does not include needle aspiration? The danger of no needle aspiration is not a mere rumor. There is a data-based reason why several nations now require (or have reinstated) needle aspiration for all vaccinations. Wherever there is risk, low or not, if there is a measure that can reduce it further, why not do that, as public policy? But just as important, why not even MENTION this issue via discussion on this program? Where there is risk, there should be choice. Uninformed, people don't know to ask for needle aspiration. Uninformed about which facilities are using this method, people don't know to choose them. These are young people who are getting myocarditis and pericarditis, some with permanent damage to their hearts. Even one "excess" (and preventable) case of this serious, preventable condition is significant. Picture it is your son. Ask if "inconvenience" seems like a reasonable justification for not doing it.

  4. It's just a mask." "It's just six feet." "It's just two weeks." "It's just non essential businesses."" It's just for the useless eaters" "It's just for non essential workers." "It's just for going into bars." "It's just for going to a restaurant" "It's just to keep from overwhelming the hospitals." "It's just to make the cases go down." "It's just to flatten the curve." "It's just a few inmates." "It's just to keep others from getting scared." "It's just for a few more weeks." "It's just a few more months" "It's just for a few more years" "It's just for going into church.” "It's just a small bracelet." "It's just a phone app." "It's just for tracing." It's just for tracking " " It's just more dying people " "It's just for the greater good" "It's just to let others know you're safe to be around." "It's just to let others know who you've been in contact with." "It's just a few more deaths." "It's just for large gatherings" "It's just a few violent protests." "It's just a vaccine." "It's just 2 vaccines" "It's just 3 vaccines" "It's just 4 vaccines" "It's just a little microchip." "It's just a blood test." "It's just a scam." "It's just for medical information." "It's just a vaccination certificate." "It's just like credit cards." "It's just a few places that don't take cash." "It's just so you can travel." "It's just so you can get your driver's license." "It's just so you can vote." "It's just 200,000 more cases" "It's just another 400,000 doses" " It's just more booster shots" "It's just another booster shot" "It's just more variants" " It's just another scientific study" "It's just another injection in your body" "It's just more studies" "It's just to not let people make their own decisions" "It's just for people with underlying causes" "It's just more lies from the CDC" "It's just more lies from the FDA" "It's just more vaccine mandates" "It's just Fauci lieing" "It's just about get the vaccination or lose your job" "It's just the Omicron BA2 variant" "It's just no scientific evidence to back this claim" "It's just until it doesn't become a threat" "It's just time to take out these tyrannical dictators" "It's just (The New World Order.)

  5. re: wanting a cold for immune diversity…. reminded hearing TWIV virologist/immunologist say wrong approach, always exposed to plenty of viruses

  6. since when are pathogens required for a good microbiome ? have you heard of commensals? this is misinformation from monica gandhi

  7. Watch this before you vaccinate children:
    Most children have natural immunity 2/10/22
    Florida breaks ranks, childhood vaccinations 3/10/22
    Inflammatory Syndrome in Children 2/23/22
    Vaccines in 5-11 Years Caused 8 Cases of Heart Problems – CDC Announces (Dec 16 2021) 12/16/21Japan
    News | Autopsy: Post-Vaccination Myocarditis “Primary Cause” of Two Teens’ Deaths 3/5/22Pfizer Vaccine Effectiveness Against Omicron Down To 12% in Kids 5-11 | New York Data 3/7/22
    Review of CDC Death Data for Ages 0-18 Streamed live on 2/10/22
    Fourth COVID jabs should not be offered until there is more evidence, says JCVI chief | English News 1/4/22
    Deaths WITH covid increase 3/1/22
    Added a Label on COVID-19 Shots to Warn About Heart Inflammation×800.jpg
    Excellent natural immunity confirmed
    Dr A Gatti discusses the presence of nanoparticles in the brains of sudden perinatal death victims 2/8/22
    Coronavirus Spike protein enhances DNA damage and suppresses immune system? 11/16/21

    Giving Injections Wrongly 11/5/21
    Need for vaccine aspiration confirmed, why is this not being done? 12/3/21
    Giving Vaccinations: Clots can form if vaccines are not aspirated before being injected. Aspirating shows when a needle has entered a
    blood vessel; blood is seen in the chamber of the needle. Vaccines should be injected into muscle tissue, not blood vessels. No one is teaching the frontliners the proper method of injecting these vaccines. The bad results of getting the vaccine in a blood vessel are: blood clots, heart problems (myocarditis, pericarditis), liver, kidney, brain and other physical problems. JAMA: mRNA vaccines elevate myocarditis risk by 133x 2/19/22
    COVID-19 vaccine protection in kids dropped during omicron surge 3/2/22
    Vaccine Caused Clotting – Study Finds The Mechanism 7/12/21
    Chances of getting heart problems after receiving vaccines: go to 18:00 minute mark at this website

    Details of Microclotting Papers By Prof. Resia Pretorius 2/9/22
    Interview with Dr. Resia Pretorius: LongCovid microclots (spike protein, apheresis + other topics) 12/18/21
    Is (Micro)clotting Causing Long Covid? | The Role of HELP Apheresis as Treatment 11/4/21
    Integrates Into DNA Of Human Liver Cells In Vitro 2/28/22
    In-Depth: Study suggests COVID-19 can alter DNA 5/13/21

    Pfizer caught hiding BOMBSHELL vaccine data 3/10/22Pfizer Vaccine
    The Pfizer documents 3/9/22
    The Truth Exposed with Dr. Peter McCullough 2/4/22
    CDC Director Rochelle Walensky Muses About the Vaccine Waning 3/8/22
    The SARS2 Pandemic: Will Truth Prevail?
    Feb 2022

    Vaccination reactions report Where to report an adverse vaccination report: 7/17/2017
    To file a COVID-19 vaccine injury claim go to this website:
    The Vaccine-injured 1/27/22

    HIDDEN COVID treatments:
    AND Dr. Paul Marik Discusses His I-MASK+Protocol (for COVID)
    The FLCCC Weekly Update, for June 16, 2021—The I-RECOVER Protocol for
    Long Haul Covid Syndrome
    Ivermectin in Africa and Brazil 3/14/22
    Ivermectin in Oklahoma 2/15/22
    Important Long Covid Information 7/21/21
    Who Gets Long Covid, and Why? | Huge Findings From New Study 11/6/20
    Dr Bruce Patterson Presentation at Georgetown University on Diagnosis and Treatment of Long COVID 2/25/22
    Spike Proteins In Immune Cells – Dr. Bruce Patterson Discusses COVID Long Haul Jun 24, 2021
    New Treatment Shows Promise for COVID Long-Haulers 7/24/21
    The Puzzle Comes Together – Why Dysfunctional Metabolism Might Explain Long Covid
    China COVID Situation – COVID Stats With Paul Bork 3/15/22
    Dysautonomia in Long Covid – How to Diagnose and Treat It | With Dr Svetlana Blitshteyn 6/14/21

    Other treatment drugs for coronaviruses: Fluvoxamine and Colchicine
    Colchicine Reduces COVID Intensity and Deaths 2/19/21
    Breaking news: ColCORONA trial (Colchicine in COVID-19) 1/26/21
    Study Shows Anti-Inflammatory Drug May Reduce Risk Of Hospitalization InCOVID-19 Patients 1/29/21
    News Roundup | Nasal Spray For COVID-19? No Mention in Big Media 2/21/22
    China COVID Situation – COVID Stats With Paul Bork 3/15/22

    Curing the Incurable with Vitamin C with Dr Thomas Levy MD, JD 10/9/20
    Brain Shrinking after Mild COVID (Oxford Study) 3/14/22

    Does God Love Everyone Unconditionally?

  8. Here is what I see in the CDC data. 1) 75% of the US population has been vaccinated. 2) 32% of children aged 5-11 have received dose 1.

    Parents took the vaccines, but in the end they were never successfully convinced of the safety. They drew the line at their children. I can't think of a better metric than that for public health failure to convince.

    Stories like whistle-blower Brook Jackson and Pfizer hiding their adverse event data give parents good reason to be concerned. I think this comparison reveals how massive is the trust gap between the public and big-pharma public health.


  10. Omicron isn't 'a little less severe' – it's a lot less severe. Why can't he say it? It is, after all, the truth.

  11. What a bunch of blowhards! These self-proclaimed windbags should be indicted for what they wrought, particularity Gandhi and Wachter. All bullshit!

  12. The protein based vaccines like NOVOVAX might be more accepted -with influenza vaccines doses are reduced by only a half from 6 months to 35 months . After 3 years old it is the full dose . It is taken up much more by at risk children .

  13. Not wearing a mask if older 60 plus or comorbidity only easy reach of antivirals -Paxlovid Remdesivir Sotrovimab and all new antivirals . TRIPLE vaxxed still get severe disease .

  14. Should you still wear a mask? We asked UCSF's Dr. Bob Wachter: Are you kidding me! What a stupid question 🙋‍♀️ after over 900 thousand dead ☠️ American 🇺🇸 people raised their hands 🙌 to say dumb ass wear you damn mask 😷 is that clear enough for you.

  15. It sounds like children should wear a cheep cloth mask to only reduce the viral load on their exposure. Is that what Yvonne meant?

  16. Pretty stunned that you continue to have Monica Gandhi representing your university considering that many well credredentialled peers have come done hard (and rightly so) on her irresponsible statements. I won't be listening to any podcasts in which she participates. You are damaging your credibility by keeping her in the public eye. The damage has been done. If she feels she can rehabilitate herself she should do it on her own-not on your university podcast.

  17. Medical authoritarinism is central problem, even worse when married to government authoritarianism. New era upon us!

  18. Masks help little as typically used but do so much long term harm. Need I list these harms? Biggest is psychological submission and social division and hatred fueled by fear and terror, encouraged by policy and blindness to harm done. Obsession does not listen to alternative views.

  19. "We could not find anyone to argue the other side" reveals something huge about ID physician psychology. Beware the experts who cannot think across issues but instead rely on fear and catastrophe driven thinking. Experts act as if they are being controlled by an anxiety, fear disorder.

  20. "Collateral damage" from mask wearing, school closures, fear induction as policy etc is spoken casually and is never given a metric. Just the potential

  21. Pfizer released date on some of the potential side effects of the covid 19 vaccine. These are the three out of the 1200 that stood out to me most as I am pregnant. Low birth weight, neonatal seizures, Stillbirth. Doctors who push this vaccine should be banned from practicing. What happened to first do no harm?

  22. The most frightening part of the virus attack…as a non medical observer… was the immediate political lens and attack mode….the virus took. It ended up destroying faith and goodwill of medical professionals. And the helplessness of the majority of wonderful knowledgeable and dedicated medical professionals … afraid to speak…. and loose their jobs or certifications because of the government bureaucrats. That should be looked into… if politics trumps science…… science stops moving in a forward direction. End of story!!!!

  23. Why do Germany and Denmark require a different technique for COVID vaccine administration? They require a slight withdrawal of the syringe plunger after needle placement to verify that no blood enters the syringe. They are concerned about the unintentional placement of the needle in a blood vessel prior to injection of the vaccine into the deltoid. Both countries think there is sufficient anatomical variation to make this a small but significant risk, especially in young males whose muscles are more innervated with blood vessels.

  24. Many of the unvaccinated who were hospitalized likely had previous, undiagnosed natural infections that afforded them no protection whatsoever. This study misrepresented the protection from natural infection for that reason. All this study showed was that natural infection, that was so symptomatic that it led to a diagnosis, afforded slight protection over vaccination. But those diagnosed natural infections were likely associated with an increased risk of autoimmune disorders that were not studied or documented!

  25. Vaccine effectiveness for 5 to 11 year old children dropped precipitously during the omicron surge. I believe it was 12 percent after 4 weeks. Pitiful efficacy.

  26. Many people I known had 3 jabs and still got infected including my sisters. You guys still encourage vaccine?!? Haizzz

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